For decades, scientists have been trying to answer one of life’s biggest questions: What makes us truly happy? Not just for the moment when we fall in love, have a child, get a present from a friend, or buy a new car, but true, lasting happiness.
The real question is what factors are responsible for long lasting happiness. The story of happiness research is full of twists, surprising discoveries and one big, clear takeaway that’s more relevant today than ever. Back in the 1980s and early 1990s, happiness wasn’t a popular topic in science. Many experts believed happiness was mostly out of our control; something determined by our genes or circumstances, not something we could change through effort or intention.
Despite the lack of science supporting any of the popular claims for happiness, marketing strategies are full of such claims. Companies like Coca-Cola, Nike, Ben & Jerry’s, Mars and even Amazon have been promoting happiness as a goal everybody can achieve by buying and consuming their products. And searching for “Happy Gut” online yields terms like “the Happy Gut Cleansing Program”, “Happy Gut Coffee” and even a book title “Happy Gut”. But does anybody really believe that any of these approaches will bring you lasting happiness?
Many of us have focused on unattainable goals or worn-out notions of happiness that don’t ultimately make us happy. It has become clear that a lot of people have realized that it isn’t stuff, promotions, being skinny, winning, or money that makes us happy and are now looking for answers. Four million people have enrolled in Laurie Santos’ wildly popular class on Coursera, The Science of Well-Being. Santos reveals misconceptions about happiness, while encouraging participants in new points of view to increase their own level of happiness.
Feeling connected to others is as fundamental as you can get to maintaining social wellness and a happy, stable life. We are nothing without our friends and family, and it extends to the broader community, both local and global. Loneliness, the opposite of belonging and happiness, has made headlines recently as Surgeon General, Vivek Murthy, has categorized it as an epidemic that has repercussions for our physical and mental health, and certainly our sense of happiness.
For a long time, psychologists thought happiness was like height: you got what you were born with, and there wasn’t much you could do about it. A 1996 study even suggested that trying to be happier might be as pointless as trying to be taller.
But a few pioneers in the study of happiness weren’t convinced. They wondered if there were habits or mindsets that could boost happiness, even a little. Was it possible that people could take steps to feel better, regardless of their circumstances?
A Shift in Psychology: Focusing on the Good
Some 20 years ago, the field of psychology was undergoing a transformation. Martin Seligman, a leading psychologist, argued that the profession had spent too much time studying mental illness and not enough on what makes life worth living. He encouraged his colleagues to focus on positive qualities like optimism, courage and social connection. This shift led to a boom in “positive psychology” and thousands of studies on happiness. Researchers tested everything from gratitude journals to meditation, from forced smiles to healthy diets.
Many of these interventions helped, but the effects were usually small and short-lived. With so many options, people were left wondering: What actually works best for lasting happiness?
Surveys about countries with the highest happiness index have been published which showed that several Scandinavian countries, including Finland ranked the highest over the last few years, even though it remained uncertain which unique aspects of Scandinavian life were responsible for these findings, even though connectedness with friends, and with nature seemed to play a role in these countries.
The Longest Study: What Really Matters in the Long Run
The most powerful answers came from a unique, decades-long study at Harvard. In 1938, researchers began following 268 Harvard undergraduates (including future President John F. Kennedy) to see what made for a healthy, happy life. Later, they added another group of men from less privileged backgrounds in Boston. Over the years, these men answered detailed questions about their lives, health and relationships. The study tracked them for more than 75 years, making it the longest-running research on happiness in history.
The Big Finding: Relationships Are Key
When psychiatrist Robert Waldinger took over the study in 2003, he was amazed by the results. After analyzing mountains of data-questionnaires, interviews, medical exams, even brain scans, one clear message stood out: The quality of your relationships is the strongest predictor of happiness and health, far more than wealth, fame, or achievement. Quoting Waldinger himself: “The clearest message that we get from this 75-year study is this: Good relationships keep us happier and healthier.
It wasn’t just being married that mattered, but being happily married. People who had warm, trusting relationships with spouses, family and friends were healthier and lived longer. Those who were lonely or had troubled relationships were more likely to suffer from health problems and feel less satisfied with life.
Why Relationships Matter So Much
The Harvard study found that social connection protects us in many ways. For example, among older adults, those in happy marriages were shielded from the negative effects of illness or pain. Even when life was tough, having someone to rely on made a huge difference.
Other research backs this up. Studies show that happy people spend less time alone and more time with others. Being socially engaged, whether through church, clubs, or simply having a large circle of friends, consistently predicts higher happiness. It’s important to note that not all relationships are equally beneficial. The quality of your connections matters more than the number. Deep, supportive, and trusting relationships are what really count. Superficial or toxic relationships can actually harm wellbeing.
Can We Really Change Our Happiness?
One challenge in happiness research is figuring out what causes what. Are happy people naturally more social, or does being social make people happier? The answer is probably a bit of both. Genetics and circumstances play a role, but so do choices and habits. The good news is that even small changes like expressing gratitude, helping others, or reaching out to friends can make a difference. Over time, these habits can strengthen your relationships and boost your overall wellbeing.
The Takeaway: Happiness Is a Team Effort
After nearly a century of research, the message is clear: You don’t have to figure out happiness alone. The most reliable path to a happy, fulfilling life is through strong, supportive relationships. It’s not about seeking instant gratification or short lasting “hedonic happiness” by chasing wealth, status, social media followers, or perfection. It’s about reaching “eudaimonic happiness” by attaining a sense of fulfillment, and wellbeing through investing in the people around you, showing kindness, and building deep connections.
Interconnectedness is a hallmark of healthy ecosystems, not just of us humans but ecosystems made up of different species of plants, animals and even microbes. Gut health has become a popular topic, and we have learned that it is the myriad of close interconnections between a large number of different microbes living in our gut, Mental disorders, including depression and social isolation have been shown to be associated with compromised gut microbial ecosystems. The health benefits of the Mediterranean diet may depend as much on the Mediterranean lifestyle (enjoying meals with friends and family) as on the particular ingredients of the diet.
So if you want to be happier, start by reaching out to someone you care about. Make time for friends and family. Enjoy meals together. Say thank you. Lend a hand. These simple acts, repeated over time, are the real “secret” to happiness, a secret that’s been hiding in plain sight all along.

Emeran Mayer, MD Is a Distinguished Research Professor in the Departments of Medicine, Physiology and Psychiatry at the David Geffen School of Medicine at UCLA, the Executive Director of the G. Oppenheimer Center for Neurobiology of Stress and Resilience and the Founding Director of the Goodman-Luskin Microbiome Center at UCLA.