Why Modern Life is Keeping Our Immune System Switched On with Will Bulsiewicz, MD

In this episode of The Mind–Gut Conversation, Dr. Emeran Mayer speaks with Will Bulsiewicz, board-certified gastroenterologist, New York Times bestselling author, and a leading voice in microbiome science.

Drawing from his latest work, Plant-Powered Plus, Dr. Bulsiewicz explains how chronic, low-grade inflammation has emerged as a central driver of many modern health conditions—and how this immune activation is shaped by diet, microbial diversity, stress, and broader lifestyle patterns.

The conversation explores the evolutionary mismatch between human biology and modern environments, the role of the gut microbiome in regulating immune responses, and why factors such as fiber intake, polyphenols, social connection, and purpose play a meaningful role in long-term health. Together, they discuss why lasting improvement depends on addressing root causes rather than relying solely on symptom-focused interventions.

This episode offers a thoughtful, evidence-based perspective on inflammation, gut health, and the practical lifestyle changes that can support immune balance and overall well-being.

Key Topics Covered:

• What chronic inflammation is and why it has become so prevalent
• How the gut microbiome and immune system communicate
• The role of fiber, polyphenols, and microbial metabolites in immune regulation
• Why modern lifestyle factors contribute to persistent immune activation
• Practical, sustainable approaches to supporting long-term health

Whether you’re navigating health concerns personally or working with patients in a clinical setting, this episode provides a grounded, science-based framework for understanding inflammation—without hype or oversimplification.