Mind-Gut Connection 101


Welcome to the Mind-Gut Connection 101 Home Page

This series of topics about the #MindGutConnection is selected from The Mind-Gut Connection book by Emeran Mayer, MD

The topics are selected chronologically, from the beginning of the book to the end. Enjoy and share these carefully selected pearls of science and wisdom from The Mind-Gut Connection.





Thanks for visiting the #MindGutConnection101 homepage. As we share these lessons, sized for sharing on social media, we will also archive them here. Please look for Dr. Emeran Mayer on Twitter, Facebook, and LinkedIn.





The #MindGutConnection offers a revolutionary new look at how the #brain, the #gut, and the trillions of #microorganisms living in the gut communicate with each other. #MindGutConnection101.1
Learn more at http://emeranmayer.com/book/

Resources supporting lesson 101.1

  1. Food As Information | The Mind-Gut Connection
  2. Interview with Dr. David Perlmutter: Diet and The Mind Gut Connection

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#MindGutConnection 101.2

The #MindGutConnection gets to the root of why the U.S. has made little progress in treating #ChronicDisease conditions, the majority of which intersect at the #BrainGutAxis (#metabolic & #neurodegenerative diseases). #MindGutConnection101.2 Learn more at  http://emeranmayer.com/book/

Resources supporting lesson 101.2

  1. Increases in health care spending
  2. World Health Organization report – ranking of U.S. health care system as highest in cost.

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#MindGutConnection 101.3

The increase in longevity in the U.S. has paralleled that of many other countries in the developed world. However, we are far behind in terms of physical & mental #WellBeing when we reach the last decades of our lives. #MindGutConnection101.3
Learn more: http://emeranmayer.com/book/

Resources supporting lesson 101.3

  1. CDC Chronic Disease Overview
  2. We are living longer than ever. But are we living better?

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#MindGutConnection 101.4

Medicine continues to view the #DigestiveSystem as being largely independent of the #brain. We now know that these two organs are intricately connected with each other, an insight reflected in the concept of a #GutBrainAxis.

Resources supporting lesson 101.4

  1. Meet your Microbiome (American Museum of Natural History)
  2. Microbiome Mind and Brain Interactions (Emeran Mayer, MD)

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#MindGutConnection 101.5

#Gut signals reaching the #brain generate #GutSensations, such as the fullness after a meal, nausea, discomfort, & feelings of #WellBeing, & also trigger brain responses back to the gut, creating distinct #GutReactions.

Resources supporting lesson 101.5

  1. Brain regulation of appetite and satiety
  2. Why we feel emotions in our guts, and what microbes have to do with it

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Dramatic technological changes in our ability to identify and characterize #microorganisms has occurred during the past decade.

Resources supporting lesson 101.6.1

  1. Separation, Identification, and Characterization of Microorganisms by Capillary Electrophoresis
  2. Use of Metatranscriptomics in Microbiome Research
  3. The Human Microbiome: Our Second Genome

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Visit the Human Microbiome Project here: https://hmpdacc.org/

Resources supporting lesson 101.6.2

  1. NIH Human Microbiome Project – List of Publications
  2. Human Microbiome Project – Data Portal
  3. The American Gut 

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One may speculate that low microbe diversity states present risk factors for developing disease.


Resources supporting lesson 101.7

  1. Changing gut bacteria through diet affects brain function, UCLA study shows
  2. How bacteria in the gut influence neurodegenerative disorders: Understanding the role of the microbiome may lead to better treatments for Parkinson’s, Alzheimer’s
  3. Brain-gut-microbiota axis in Parkinson’s disease

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There is growing evidence that the mix of falls out of its healthy stable state in several gut disorders, a state called . #MindGutConnection101.8 Learn more:

Resources supporting lesson 101.8

  1. Gastrointestinal dysbiosis
  2. Dysbiosis of the gut microbiota in disease

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The similarities in the time course of new epidemics suggest a common underlying mechanism related to a change in our during the last fifty years. #MindGutConnection101.9

Resources supporting lesson 101.9

  1. Gut Microbes and the Brain: Paradigm Shift in Neuroscience
  2. The changing microbial landscape of Western society: Diet, dwellings and discordance

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Some #microbes find their way into the bloodstream and are involved in long-distance signaling, influencing every organ, including the brain. #MindGutConnection101.10.1

Resources supporting lesson 101.10.1

  1. Understanding the constant dialogue that goes on between our gut and our brain
  2. Gut microbial communities modulating brain development and function
  3. Signaling in host-associated microbial communities

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Inflammatory molecules affect certain brain regions and may well be a major clue to our understanding of many human brain disorders. #MindGutConnection101.10.2

Resources supporting lesson 101.10.2

  1. The Gut Microbiome and the Brain
  2. Gut Feelings: Bacteria and the Brain
  3. From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways
  4. The gut-brain axis: is intestinal inflammation a silent driver of Parkinson’s disease pathogenesis?
  5. The Brain-Gut-Microbiome Axis

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A paradigm shift in our thinking about the body is essential to keep our , and therefore our whole selves, healthy and resilient against disease. #MindGutConnection101.11

Resources supporting lesson 101.11
  1. Diversity, stability and resilience of the human gut microbiota
  2. Diversity, Stability, and Resilience of the Human Microbiome
  3. Human Gut Microbiota: Toward an Ecology of Disease
  4. Human gut bacterial ecosystem – definition

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Your , , and are uniquely connected. #MindGutConnection101.12

Resources supporting lesson 101.12

  1. Think Twice: How the Gut’s “Second Brain” Influences Mood and Well-Being
  2. Some Gut Feelings Are A Red Flag
  3. Gut–brain axis – Wikipedia

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Emotions reflect in our facial expressions and also in different regions of the #GastrointestinalTract – influenced by signals from the #LimbicSystem. Signals to the upper & lower GI tract can synchronous or asynchronous. #MindGutConnection101.13

Resources supporting lesson 101.13

  1. Human Emotions Really Are Affected by Gut Bacteria, New Study Suggests
  2. Association between gut bacteria and emotion, suggests study
  3. The microbiota–gut–brain axis: neurobehavioral correlates, health and sociality

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Of the many patients I have seen in my long career as a #gastroenterologist, Bill stands out in my memory more than any other. Patients with stressful life events can suffer from #CyclicalVomitingSyndrome.
Read more: http://emeranmayer.com/book/

Resources supporting lesson 101.14

  1. Cyclic vomiting syndrome
  2. Cyclic Vomiting Syndrome – A Disorder of All Ages
  3. Cyclic vomiting syndrome: evolution in our understanding of a brain-gut disorder.

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speak! (ACTH or adrenocorticotropic hormone) is a produced & secreted by the . It is an important player in the . #MindGutConnection101.15 Learn more:

Resources supporting lesson 101.15

  1. Adrenocorticotropic hormone
  2. Adrenocorticotropic Hormone (ACTH, Corticotropin)
  3. Adrenocorticotropic hormone – Society for Endocrinology

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Your is networked with complex systems in the body. Trillions of bacteria in the gut communicate with cells (which they greatly outnumber). .16 Learn more: emeranmayer.com/book/
Resources supporting lesson 101.16


Army surgeon Dr. William Beaumont (November 21, 1785 – April 25, 1853) became the first scientist in history to report that your emotions can influence the activity of your stomach. .17 Learn more:
Resources for Lesson 101.17


Once an emotional motor program has been triggered, its effects may linger for hours—or sometimes for years. .19 Learn more:
Resources supporting lesson #101.19


Emotions always have a mirror image in our . Detrimental effects from chronic anger, sorrow, or fear may exert not only on our but also on our overall . .20 Learn more:
Resources supporting lesson #101.20