Mind-Gut Connection 101

#MindGutConnection101

Welcome to the Mind-Gut Connection 101 Home Page

This series of topics about the #MindGutConnection is selected from The Mind-Gut Connection book by Emeran Mayer, MD

The topics are selected chronologically, from the beginning of the book to the end. Enjoy and share these carefully selected pearls of science and wisdom from The Mind-Gut Connection.

 

 

 

 

Thanks for visiting the #MindGutConnection101 homepage. As we share these lessons, sized for sharing on social media, we will also archive them here. Please look for Dr. Emeran Mayer on Twitter, Facebook, and LinkedIn.

 

 

 

#MindGutConnection101.1

The #MindGutConnection offers a revolutionary new look at how the #brain, the #gut, and the trillions of #microorganisms living in the gut communicate with each other. #MindGutConnection101.1
Learn more at http://emeranmayer.com/book/

Resources supporting lesson 101.1

  1. Food As Information | The Mind-Gut Connection
  2. Interview with Dr. David Perlmutter: Diet and The Mind Gut Connection

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#MindGutConnection 101.2

The #MindGutConnection gets to the root of why the U.S. has made little progress in treating #ChronicDisease conditions, the majority of which intersect at the #BrainGutAxis (#metabolic & #neurodegenerative diseases). #MindGutConnection101.2 Learn more at  http://emeranmayer.com/book/

Resources supporting lesson 101.2

  1. Increases in health care spending
  2. World Health Organization report – ranking of U.S. health care system as highest in cost.

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#MindGutConnection 101.3

The increase in longevity in the U.S. has paralleled that of many other countries in the developed world. However, we are far behind in terms of physical & mental #WellBeing when we reach the last decades of our lives. #MindGutConnection101.3
Learn more: http://emeranmayer.com/book/

Resources supporting lesson 101.3

  1. CDC Chronic Disease Overview
  2. We are living longer than ever. But are we living better?

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#MindGutConnection 101.4

Medicine continues to view the #DigestiveSystem as being largely independent of the #brain. We now know that these two organs are intricately connected with each other, an insight reflected in the concept of a #GutBrainAxis.
#MindGutConnection101.4
http://emeranmayer.com/book/

Resources supporting lesson 101.4

  1. Meet your Microbiome (American Museum of Natural History)
  2. Microbiome Mind and Brain Interactions (Emeran Mayer, MD)

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#MindGutConnection 101.5

#Gut signals reaching the #brain generate #GutSensations, such as the fullness after a meal, nausea, discomfort, & feelings of #WellBeing, & also trigger brain responses back to the gut, creating distinct #GutReactions.
#MindGutConnection101.5
http://emeranmayer.com/book/

Resources supporting lesson 101.5

  1. Brain regulation of appetite and satiety
  2. Why we feel emotions in our guts, and what microbes have to do with it

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#MindGutConnection101.6.1

Dramatic technological changes in our ability to identify and characterize #microorganisms has occurred during the past decade.
#MindGutConnection101.6.1
http://emeranmayer.com/book/

Resources supporting lesson 101.6.1

  1. Separation, Identification, and Characterization of Microorganisms by Capillary Electrophoresis
  2. Use of Metatranscriptomics in Microbiome Research
  3. The Human Microbiome: Our Second Genome

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#MindGutConnection101.6.2

#MindGutConnection101.6.2
Visit the Human Microbiome Project here: https://hmpdacc.org/

Resources supporting lesson 101.6.2

  1. NIH Human Microbiome Project – List of Publications
  2. Human Microbiome Project – Data Portal
  3. The American Gut 

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#MindGutConnection101.7

One may speculate that low microbe diversity states present risk factors for developing disease.
#MindGutConnection101.7

http://emeranmayer.com/book/

Resources supporting lesson 101.7

  1. Changing gut bacteria through diet affects brain function, UCLA study shows
  2. How bacteria in the gut influence neurodegenerative disorders: Understanding the role of the microbiome may lead to better treatments for Parkinson’s, Alzheimer’s
  3. Brain-gut-microbiota axis in Parkinson’s disease

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#MindGutConnection101.8

There is growing evidence that the mix of falls out of its healthy stable state in several gut disorders, a state called . #MindGutConnection101.8 Learn more:

Resources supporting lesson 101.8

  1. Gastrointestinal dysbiosis
  2. Dysbiosis of the gut microbiota in disease

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#MindGutConnection101.9

The similarities in the time course of new epidemics suggest a common underlying mechanism related to a change in our during the last fifty years. #MindGutConnection101.9
http://emeranmayer.com/book

Resources supporting lesson 101.9

  1. Gut Microbes and the Brain: Paradigm Shift in Neuroscience
  2. The changing microbial landscape of Western society: Diet, dwellings and discordance

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#MindGutConnection101.10.1

Some #microbes find their way into the bloodstream and are involved in long-distance signaling, influencing every organ, including the brain. #MindGutConnection101.10.1
http://emeranmayer.com/book

Resources supporting lesson 101.10.1

  1. Understanding the constant dialogue that goes on between our gut and our brain
  2. Gut microbial communities modulating brain development and function
  3. Signaling in host-associated microbial communities

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#MindGutConnection101.10.2

Inflammatory molecules affect certain brain regions and may well be a major clue to our understanding of many human brain disorders. #MindGutConnection101.10.2

Resources supporting lesson 101.10.2

  1. The Gut Microbiome and the Brain
  2. Gut Feelings: Bacteria and the Brain
  3. From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways
  4. The gut-brain axis: is intestinal inflammation a silent driver of Parkinson’s disease pathogenesis?
  5. The Brain-Gut-Microbiome Axis

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#MindGutConnection101.11

A paradigm shift in our thinking about the body is essential to keep our , and therefore our whole selves, healthy and resilient against disease. #MindGutConnection101.11

Resources supporting lesson 101.11
  1. Diversity, stability and resilience of the human gut microbiota
  2. Diversity, Stability, and Resilience of the Human Microbiome
  3. Human Gut Microbiota: Toward an Ecology of Disease
  4. Human gut bacterial ecosystem – definition

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#MindGutConnection101.12

Your , , and are uniquely connected. #MindGutConnection101.12

Resources supporting lesson 101.12

  1. Think Twice: How the Gut’s “Second Brain” Influences Mood and Well-Being
  2. Some Gut Feelings Are A Red Flag
  3. Gut–brain axis – Wikipedia

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#MindGutConnection101.13

Emotions reflect in our facial expressions and also in different regions of the #GastrointestinalTract – influenced by signals from the #LimbicSystem. Signals to the upper & lower GI tract can synchronous or asynchronous. #MindGutConnection101.13
http://emeranmayer.com/book/

Resources supporting lesson 101.13

  1. Human Emotions Really Are Affected by Gut Bacteria, New Study Suggests
  2. Association between gut bacteria and emotion, suggests study
  3. The microbiota–gut–brain axis: neurobehavioral correlates, health and sociality

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#MindGutConnection101.14

Of the many patients I have seen in my long career as a #gastroenterologist, Bill stands out in my memory more than any other. Patients with stressful life events can suffer from #CyclicalVomitingSyndrome.
#MindGutConnection101.14
Read more: http://emeranmayer.com/book/

Resources supporting lesson 101.14

  1. Cyclic vomiting syndrome
  2. Cyclic Vomiting Syndrome – A Disorder of All Ages
  3. Cyclic vomiting syndrome: evolution in our understanding of a brain-gut disorder.

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#MindGutConnection101.15

speak! (ACTH or adrenocorticotropic hormone) is a produced & secreted by the . It is an important player in the . #MindGutConnection101.15 Learn more:

Resources supporting lesson 101.15

  1. Adrenocorticotropic hormone
  2. Adrenocorticotropic Hormone (ACTH, Corticotropin)
  3. Adrenocorticotropic hormone – Society for Endocrinology

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#MindGutConnection101.16

Your is networked with complex systems in the body. Trillions of bacteria in the gut communicate with cells (which they greatly outnumber). .16 Learn more: emeranmayer.com/book/
Resources supporting lesson 101.16

#MindGutConnection101.17

Army surgeon Dr. William Beaumont (November 21, 1785 – April 25, 1853) became the first scientist in history to report that your emotions can influence the activity of your stomach. .17 Learn more:
Resources supporting Lesson 101.17

#MindGutConnection101.19

Once an emotional motor program has been triggered, its effects may linger for hours—or sometimes for years. .19 Learn more:
Resources supporting lesson #101.19

#MindGutConnection101.20

Emotions always have a mirror image in our . Detrimental effects from chronic anger, sorrow, or fear may exert not only on our but also on our overall . .20 Learn more:
Resources supporting lesson #101.20

#MindGutConnection101.21

When the gut talks, not everyone is listening.
#MindGutConnection101.21
Learn more: http://emeranmayer.com/book/
Resources supporting lesson 101.21
  1. Our gut talks and sometimes argues with our brain. Now we know how.
  2. The brain and the gut talk to each other: how fixing one could help the other
  3. How the gut talks to the brain

  4. (Click to retweet)

#MindGutConnection101.22

What could have triggered Frank’s hypersensitivity to #GutSensations?#MindGutConnection101.22
Learn more: http://emeranmayer.com/book/

Resources supporting lesson 101.22

  1. Hypersensitivity in functional gastrointestinal disorders 
  2. Gut pain & visceral hypersensitivity
  3. The Sensitive Gut

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#MindGutConnection101.23

Receptors in your gut stimulate the release of several hormones that signal the brain, creating a sense of satiety.
#MindGutConnection101.23
Learn more: http://emeranmayer.com/book/

Resources supporting lesson 101.23

  1. Brain regulation of appetite and satiety
  2. The impact of gut hormones on the neural circuit of appetite and satiety: A systematic review
  3. Emerging role of the brain in the homeostatic regulation of energy and glucose metabolism

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#MindGutConnection101.24

Your #gut has a lot to say.
Are you listening?
#MindGutConnection101.24
Learn more: http://emeranmayer.com/book/

Resources supporting lesson 101.24

  1. Interoception and emotion
  2. Interoceptive cues: When ‘gut feelings’ point to anxiety
  3. Feeling Biology: Interoceptive Meditation and the Perception of Self

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#MindGutConnection101.25

The #VagusNerve is more than a one-way communication channel:
This nerve is a six-lane freeway, allowing rush hour traffic in both directions, and 90% of this traffic flows from the #gut to the #brain.

#MindGutConnection101.25

Learn more: http://emeranmayer.com/book/

Resources supporting lesson 101.25

  1. The Microbiome-Gut-Brain Axis Relies on Your Vagus Nerve

  2. Why we feel emotions in our guts, and what microbes have to do with it

  3. Understanding the constant dialogue that goes on between our gut and our brain

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#MindGutConnection101.26

#Serotonin is the ultimate #GutBrain signaling molecule.
#MindGutConnection101.26
Learn more: http://emeranmayer.com/book/

Resources supporting lesson 101.26

  1. The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems

  2. Brain Gut Microbiome Interactions and Functional Bowel Disorders

  3. The Gut Brain Connection: How Your Gut Holds the Key to Better Brain Health by Dr. Emeran Mayer

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#MindGutConnection101.27

#FoodAsInformation
The #gut is an amazing information-processing machine that greatly surpasses our brains in terms of the total number of cells involved, and rivals some of the brain’s capabilities.
#MindGutConnection101.27
Learn more: http://emeranmayer.com/book/

Resources supporting lesson 101.27

Food for thought: The role of nutrition in the microbiota-gut–brain axis

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#MindGutConnection101.28

In a subsequent review article, Pierre Baldi and myself discussed the concept of a #UniversalBiologicalLanguage made up of signals generated by the gut.

#MindGutConnection101.28

Learn more: http://emeranmayer.com/book/

Resources supporting lesson 101.28

  1. Can regulatory peptides be regarded as words of a biological language

  2. Do All Diseases Start in the Soil?

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#MindGutConnection101.29

The changes in the normal development of a healthy can put patients at risk of developing symptoms as well as a lifelong miscommunication between the and the . .29 Learn more:

Learn more: http://emeranmayer.com/book/

Resources supporting lesson 101.29

  1. Perinatal programming of gut microbiota and immunity

  2. Gut microbiota and developmental programming of the brain: from evidence in behavioral endophenotypes to novel perspective in obesity
  3. Programming infant gut microbiota: influence of dietary and environmental factors

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#MindGutConnection101.30

Some transient , e.g., parasites and viruses, have learned to hack into our most sophisticated computer system, the brain, to use its emotional operating programs for their own selfish benefits. .30 Learn more:
Learn more: http://emeranmayer.com/book/

Resources supporting lesson 101.30

  1. COMING SOON!

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#MindGutConnection101.31

The , the in the , was left in charge of the basic digestive functions, a division of labor that has persisted in the human . .32.2
Learn more:

Resources supporting lesson 101.31

  1. Think Twice: How the Gut’s “Second Brain” Influences Mood and Well-Being

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#MindGutConnection101.32.1

made contact with the primitive of marine animals millions of years ago. The long evolutionary journey explains why our , & continue to influence our & . .32.1
Learn more: 

  1. COMING SOON!

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#MindGutConnection101.32.2

The , the in the , was left in charge of the basic digestive functions, a division of labor that has persisted in the human . .32.2
Learn more:

  1. COMING SOON!

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#MindGutConnection101.32.3

As more complex types of polar animals evolved (e.g. with a head), primitive grew into a more elaborate network of nerves outside the . .32.3
Learn more: emeranmayer.com/book/

Resources supporting lesson 101.32.3

  1. COMING SOON!

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#MindGutConnection101.32.4

These functions were eventually transferred to regions of the brain, while the was left in charge of basic digestive functions, a division of labor that persisted in our . .32.4
Learn more: http://emeranmayer.com/book/

Resources supporting lesson 101.32.4

  1. COMING SOON!

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#MindGutConnection101.33

Respecting the key points of this ancient binding contract has produced a remarkably peaceful and mutually beneficial coexistence between microbes and hosts that has persisted for millions of years. .33
Learn more:

Resources supporting lesson 101.33

  1. COMING SOON!

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#MindGutConnection101.34

There are several ways by which this microbe-immune system-brain dialogue can take place.101.34
Learn more: http://emeranmayer.com/book/

Resources supporting lesson 101.34

  1. COMING SOON!

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#MindGutConnection101.35

Millions of conversations being held right now at the intersection of the & . .35
Learn more: http://emeranmayer.com/book/

Resources supporting lesson 101.35

  1. COMING SOON!

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#MindGutConnection101.36

It has become clear that the , the , and the are all in constant, close communication. .36
Learn more: http://emeranmayer.com/book/

Resources supporting lesson 101.36

  1. COMING SOON!

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#MindGutConnection101.37

Your brain, gut & microbiome are all communicating with each other – but are you supporting the conversation? provides practical, evidence-based recommendations to keep the dialogue flowing smoothly. .37 Learn more:

Resources supporting lesson 101.37

  1. COMING SOON!

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#MindGutConnection101.38

When you’re stressed, the main stress molecule that we secrete, , gets to the microbes, changes their gene expression, & makes them secrete different things, resulting in a change of their behavior. .38
Learn more: http://emeranmayer.com/book/

Resources supporting lesson 101.38

  1. Stress & the gut-brain axis: Regulation by the microbiome

  2. The microbiome: A key regulator of stress and neuroinflammation

  3. Gut–brain axis: how the microbiome influences anxiety and depression

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#MindGutConnection101.39

The know what state of mood you’re in, and at the same time, our brain knows the signals that microbes send up to us. It’s a communication that we are totally unaware of, yet it plays such an important role. .39
Learn more:

Resources supporting lesson 101.39

  1. COMING SOON!

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#MindGutConnecton101.40

Studies have shown similar types of “intergenerational transmission” of stress and adversity. #MindGutConnection101.40 Learn more:

Resources supporting lesson 101.40

  1. COMING SOON!

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#MindGutConnecton101.41

tags are the bookmarks and highlighting that tell a brain cell to read one passage of the book and a liver or heart cell to read another. .41 Learn more:

Resources supporting lesson 101.41

 

  1. COMING SOON!

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#MindGutConnecton101.42

What benefit is there to suffer from symptoms throughout life as a “side effect” unintended by evolution? .42 Learn more:

Resources supporting lesson 101.42

  1. COMING SOON!

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#MindGutConnecton101.43

Stress-induced changes in the and their products can affect the brain. Interventions have to start early in life if we want to have an impact on devastating diseases. -The Mind-Gut Connection .43

Resources supporting lesson 101.43

  1. COMING SOON!

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#MindGutConnecton101.44

The mother’s also supply our newborns with a key piece of its machinery, giving the baby the ability to digest the milk sugars and special carbohydrates in breast milk. .44 Learn more:

Resources supporting lesson 101.44

  1. In a Mother’s Milk, Nutrients, and a Message, Too

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#MindGutConnecton101.45

Why would evolution develop a system that makes us unhealthy & unhappy? Nature devises strategies for humans to deal with stress that include our , before, during, & after birth, with lifelong consequences. .45 Learn more:

Resources supporting lesson 101.45

  1. The healthy human microbiome

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#MindGutConnecton101.46

Your early experiences, while still in the womb, can play a role in the development of your and disorders, and possibly affect your , including and . .46 Learn more:

Resources supporting lesson 101.46

  1. The gut microbiome: How does it affect our health?

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#MindGutConnecton101.47.1

Therapies can help us learn new behaviors, like adding new code to an existing computer program that can override flaws in the program. Such therapies include , , or . .47.1 Learn more:

Resources supporting lesson 101.47.1

  1. Psychological Interventions for Irritable Bowel Syndrome and Inflammatory Bowel Diseas

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#MindGutConnecton101.47.2

Good news from recent research: These therapeutic approaches can actually change the wiring of our brains, helping the exert some control on an overactive emotional . .47.2 Learn more:

Resources supporting lesson 101.47.2

  1. Psychotherapy for Irritable Bowel Syndrome

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#MindGutConnecton101.48

Emotional feelings are quintessential to what makes us human. Revolutionary findings suggest that the in our play a critical role in the complex interactions between mind, brain, and gut. .48 Learn more:

Resources supporting lesson 101.48

  1. Some Gut Feelings Are A Red Flag

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#MindGutConnecton101.49

The “microbiome-free” worldview of neuroscience has dramatically changed with the discovery and characterization of the human microbiome and, in particular, with the gut microbiome. .49 Learn more:

Resources supporting lesson 101.49

  1. Gut Microbes and the Brain: Paradigm Shift in Neuroscience

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#MindGutConnecton101.50

Many of our medications, such as Valium, Xanax, and Klonopin, target the same signaling systems as our gut do, mimicking the effects of . .50 Learn more:

Resources supporting lesson 101.50

  1. The Gut Microbiome and the Brain

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#MindGutConnecton101.ComingSoon!

Resources supporting lesson 101.ComingSoon!

  1. COMING SOON!

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